DNA damage, p53 and the p53–MDM2 feedback loop

Arrowhead: activates. Flat bar: inhibits. Dashed line: switches on the gene. Solid line: acts on the protein.

Click a molecule in the diagram, or use the buttons below, to see its interactions and the papers behind them.

Show interactions by mechanism Phosphorylation Switching on a gene Binding or degradation Other

Molecules

Table of interactions (the same information as the diagram)

All 12 interactions in the diagram, with the papers that support them
From	Effect	To	How	Sources